Consider that the largest human cells are about the diameter of a human hair. Bacteria cells are one-hundredth the size of a human cell and viruses are much, much smaller again. If you imagine that a single virus was the size of an adult human, a bacterium (single cell) would be over 10 storeys high by comparison. A bacterium next to a human cell is like a tiny boat next to a big ship. Hundreds of thousands of bacteria could fit onto a pinhead.

The main microorganisms in and on our bodies are protozoa, algae, fungi, bacteria and viruses. Most microorganisms are beneficial, for example, there are microorganisms in our large intestine that synthesise vitamins and allow them to be absorbed into the bloodstream. However, a tiny minority are pathogens (disease-causing agents). These pathogens, often called germs or bugs, are a threat to all life forms.

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Because microorganisms include most unicellular organisms from all three domains of life they can be extremely diverse. Two of the three domains, Archaea and Bacteria, only contain microorganisms. The third domain Eukaryota includes all multicellular organisms as well as many unicellular protists and protozoans that are microbes. Some protists are related to animals and some to green plants. There are also many multicellular organisms that are microscopic, namely micro-animals, some fungi, and some algae, but these are generally not considered microorganisms.

Microbes are important in human culture and health in many ways, serving to ferment foods, and to produce fuel, enzymes, and other bioactive compounds. Microbes are essential tools in biology as model organisms and have been put to use in biological warfare and bioterrorism. Microbes are a vital component of fertile soil. In the human body, microorganisms make up the human microbiota, including the essential gut flora. The pathogens responsible for many infectious diseases are microbes and, as such, are the target of hygiene measures.

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Microorganisms are found virtually everywhere, except for environments that have been made artificially sterile by humans. Even these must be constantly sterilized and carefully protected, lest microorganisms be tracked in from the outside world.

Microorganisms live in water, in soil, and on the skin and in the digestive tracts of animals. This is why all living things must have immune systems – while many microorganisms can be helpful to them, some can be harmful and cause disease.

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